DEEP BRAIN STIMULATION IN PARKINSON’S DISEASE
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Abstract
Parkinson’s disease is caused mainly by the loss of dopaminergic neurons of the substantia nigra pars compacta that change the activity pattern in the basal nuclei. Levodopa has been the central pillar in the treatment of this disease since 1960’s, but its adverse effects like dyskinesia and motor fluctuations makes surgery a reemergent treatment as an adjuvant. The treatment of motor symptoms can be achieved with deep brain stimulation which is a pretty safe technique that has shown good results. The subthalamic nucleus and internal globus pallidus are the main targets used nowadays. The best results in motor symptoms and quality of life are achieved by adequate selection of patients.
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